How do I install Folklore Clinical Variant Interpretation MCP?

Copy the http config for Cursor, Claude Desktop, Claude Code, or VS Code on this page. It uses the publisher's install, not a PlugMCP proxy.

Does Folklore Clinical Variant Interpretation MCP need an API key?

No required environment variable is listed on this record.

What transport does Folklore Clinical Variant Interpretation MCP use?

Folklore Clinical Variant Interpretation MCP is reached over HTTP.

Folklore Clinical Variant Interpretation MCP server

Q: When was Folklore Clinical Variant Interpretation MCP last checked?

Last checked 2026-10-31. Folklore MCP 2.0.0 provides germline ACMG/AMP variant classification, gene profiles, disease associations, and literature search. The shared remote endpoint exposes 11 public tools. An optional Folklore API key enables 18 additional tools for submitting and tracking cases, browsing approved source files, and retrieving JSON or PDF results and six structured report views. Analysis uses the limits and credits of the associated Folklore account. Endpoint: https://api.helena.bio/folklore/v1/mcp Setup and tool reference: https://folklore.helena.bio/integrations/mcp

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Server URL

https://api.helena.bio/folklore/v1/mcp

The Claude button above opens Claude with the name and URL filled in. You still confirm it there.

shClaude Code

1claude mcp add --transport http io.github.helena-bioinformatics-folklore https://api.helena.bio/folklore/v1/mcp

Run in a terminal.

jsonClaude Desktop

1{2  "mcpServers": {3    "io.github.helena-bioinformatics-folklore": {4      "command": "npx",5      "args": [6        "-y",7        "mcp-remote",8        "https://api.helena.bio/folklore/v1/mcp"9      ]10    }11  }12}

claude_desktop_config.json

Remote · HTTPPublisher installStep-by-step: add this in Claude

Remote URL or a command on your machine? How the two installs differ

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Host a copy with our keys and logs.

A new server you create. It is not this listing's official endpoint. Use the publisher install when you want their URL and their credentials.

Launch

Server facts

Live

Transport: http
Version: 2.0.0
Last checked

Overview

About Folklore Clinical Variant Interpretation MCP

Folklore MCP 2.0.0 provides germline ACMG/AMP variant classification, gene profiles, disease associations, and literature search. The shared remote endpoint exposes 11 public tools. An optional Folklore API key enables 18 additional tools for submitting and tracking cases, browsing approved source files, and retrieving JSON or PDF results and six structured report views. Analysis uses the limits and credits of the associated Folklore account. Endpoint: https://api.helena.bio/folklore/v1/mcp Setup and tool reference: https://folklore.helena.bio/integrations/mcp

11 tools

Tools

tools/listVoice mode preview

Tool	What it does
classify_germline_variant	Classify one GRCh38 germline nuclear SNV or simple indel smaller than 50 bp under ACMG/AMP. Accepts genomic, coding or protein HGVS, coordinates, SPDI, rsID or a returned canonical key. Returns normalized identity, automated classification, applied criteria, ClinVar assertions, population frequencies, annotations and source provenance when available. Ambiguous input returns candidates for selection.
get_gene_disease_associations	Find diseases associated with an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance, including conflicting and limited assertions.
get_gene_profile	Read the selected gene_id and immutable snapshot_id from resolve_gene. Returns overview, disease validity, dosage, mechanisms, transcripts, native assemblies, constraint, ClinVar summaries and consequences, expression, GWAS, phenotypes and protein/pathways with source assertions, coverage, count units and null values. get_gene_section supplies further pages. Live search_gene_literature is separate from the snapshot literature section.
get_gene_section	Read a gene-profile section using gene_id, snapshot_id and its returned opaque cursor. Returns source records, assembly/release, coverage, totals, count units and provenance. snapshot_unavailable requires a fresh resolution/profile request.
get_publication_details	Retrieve one PMID from the PubMed-derived genetics corpus, including title, abstract, authors, journal, publication types, MeSH terms, gene and variant mentions, retraction status and PubMed/PMC links.
resolve_gene	Resolve a human gene symbol, previous symbol, alias, HGNC, Ensembl or NCBI Gene identifier. Returns exact, alias, ambiguous, not_found or withdrawn status with candidates and identity_snapshot_id. Use a selected HGNC gene_id and snapshot_id with get_gene_profile. Gene-plus-HGVS and variant expressions use classify_germline_variant.
search_disease_genes	Find genes associated with an exact MONDO identifier or disease-name search. Returns ClinGen validity assertions with inheritance, source reports and snapshot provenance. Name searches can return multiple disease identities.
search_gene_literature	Retrieve a live publication capture for a resolved gene_id and snapshot_id. Returns source links, match labels, capture time/hash, degradation and gene/snapshot/sort-bound cursors. This capture is separate from the immutable reference snapshot and contains no abstracts.
search_literature_corpus	Search the genetics Literature Corpus by question, PMID, DOI, PMCID, gene, variant, phenotype, HPO or OMIM concept. Known publication identifiers provide exact anchors. Returns ranked publications, match types, scores and source links.
search_variant_literature	Resolve one GRCh38 germline variant and retrieve publications from the PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Returns match types, source links, corpus provenance and retrieval time.
support_helena	Retrieve Helena Good campaign, rules, manifest and MCP connection URLs.

Tool

What it does

classify_germline_variant

Classify one GRCh38 germline nuclear SNV or simple indel smaller than 50 bp under ACMG/AMP. Accepts genomic, coding or protein HGVS, coordinates, SPDI, rsID or a returned canonical key. Returns normalized identity, automated classification, applied criteria, ClinVar assertions, population frequencies, annotations and source provenance when available. Ambiguous input returns candidates for selection.

get_gene_disease_associations

Find diseases associated with an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance, including conflicting and limited assertions.

get_gene_profile

Read the selected gene_id and immutable snapshot_id from resolve_gene. Returns overview, disease validity, dosage, mechanisms, transcripts, native assemblies, constraint, ClinVar summaries and consequences, expression, GWAS, phenotypes and protein/pathways with source assertions, coverage, count units and null values. get_gene_section supplies further pages. Live search_gene_literature is separate from the snapshot literature section.

get_gene_section

Read a gene-profile section using gene_id, snapshot_id and its returned opaque cursor. Returns source records, assembly/release, coverage, totals, count units and provenance. snapshot_unavailable requires a fresh resolution/profile request.

get_publication_details

Retrieve one PMID from the PubMed-derived genetics corpus, including title, abstract, authors, journal, publication types, MeSH terms, gene and variant mentions, retraction status and PubMed/PMC links.

resolve_gene

Resolve a human gene symbol, previous symbol, alias, HGNC, Ensembl or NCBI Gene identifier. Returns exact, alias, ambiguous, not_found or withdrawn status with candidates and identity_snapshot_id. Use a selected HGNC gene_id and snapshot_id with get_gene_profile. Gene-plus-HGVS and variant expressions use classify_germline_variant.

search_disease_genes

Find genes associated with an exact MONDO identifier or disease-name search. Returns ClinGen validity assertions with inheritance, source reports and snapshot provenance. Name searches can return multiple disease identities.

search_gene_literature

Retrieve a live publication capture for a resolved gene_id and snapshot_id. Returns source links, match labels, capture time/hash, degradation and gene/snapshot/sort-bound cursors. This capture is separate from the immutable reference snapshot and contains no abstracts.

search_literature_corpus

Search the genetics Literature Corpus by question, PMID, DOI, PMCID, gene, variant, phenotype, HPO or OMIM concept. Known publication identifiers provide exact anchors. Returns ranked publications, match types, scores and source links.

search_variant_literature

Resolve one GRCh38 germline variant and retrieve publications from the PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Returns match types, source links, corpus provenance and retrieval time.

support_helena

Retrieve Helena Good campaign, rules, manifest and MCP connection URLs.

Folklore Clinical Variant Interpretation MCP

Add this server

Host a copy with our keys and logs.

Server facts

About Folklore Clinical Variant Interpretation MCP

Tools

Questions

How do I install Folklore Clinical Variant Interpretation MCP?

Does Folklore Clinical Variant Interpretation MCP need an API key?

What transport does Folklore Clinical Variant Interpretation MCP use?

When was Folklore Clinical Variant Interpretation MCP last checked?

Documentation